Erratum: Cancer drug developers counteract kinase gatekeeper mutations
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چکیده
منابع مشابه
Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase.
Protein kinases are therapeutic targets for human cancer. However, "gatekeeper" mutations in tyrosine kinases cause acquired clinical resistance, limiting long-term treatment benefits. mTOR is a key cancer driver and drug target. Numerous small-molecule mTOR kinase inhibitors have been developed, with some already in human clinical trials. Given our clinical experience with targeted therapeutic...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2015
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4797